Synthesis and preliminary biological studies of 3-substituted indoles accessed by a palladium-catalyzed enantioselective alkene difunctionalization reaction.
نویسندگان
چکیده
A unique alkene difunctionalization reaction that allows rapid construction of molecular complexity around the biologically relevant indole framework has been developed. The reaction proceeds with up to 87% yield, 99:1 er, and >20:1 dr. Evaluation of several of the compounds revealed promising anticancer activity against MCF-7 cells.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 132 23 شماره
صفحات -
تاریخ انتشار 2010